2. Academic Validation
  3. Investigating the therapeutic effects of Shenzhiling oral liquid on Alzheimer's disease: a network pharmacology and experimental approach

Investigating the therapeutic effects of Shenzhiling oral liquid on Alzheimer's disease: a network pharmacology and experimental approach

  • 3 Biotech. 2025 Jan;15(1):14. doi: 10.1007/s13205-024-04181-6.
Gaofeng Qin 1 2 3,  Rongqiang Song 2,  Jingyi Sun 4,  Bing Chen 2,  Zhe Liu 2,  Lei Han 5,  Baoliang Sun 1 6,  Chen Li 2 3
Affiliations

Affiliations

  • 1 Shandong University of Traditional Chinese Medicine, Jinan, Shangdong China.
  • 2 Department of Traditional Chinese Medicine, Binzhou Medical University Hospital, Binzhou, 256603 Shandong China.
  • 3 Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong China.
  • 4 Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong China.
  • 5 Department of Reproductive Medicine, Binzhou Medical University Hospital, Binzhou, Shandong China.
  • 6 Shandong First Medical University & Shandong Academy of Medical Sciences, Second Affiliated Hospital, Taian, 271000 Shandong China.
PMID: 39703418 DOI: 10.1007/s13205-024-04181-6
Abstract

There is currently no effective treatment for Alzheimer's disease (AD). This research explored Shenzhiling Oral Liquid (SZLD) against AD by pinpointing crucial elements and understanding its molecular mechanisms through network pharmacology and in vitro experiment. First, we used network pharmacology to screen the main targets and mechanisms of SZLD to improve AD. Then we conducted experiments with Aβ42-induced SH-SY5Y cells to assess SZLD's impact, focusing particularly on apoptotic pathways, thereby uncovering its mechanism of action in AD. Through our analysis, we discovered a notable link between SZLD's effect on AD and Apoptosis processes. Specifically, the critical proteins Casapse3 and Bcl-2 showed strong correlations in this context. Through systematic data analysis and experimental verification, we unveiled the healing advantages and the foundational molecular mechanisms of SZLD in AD. These findings underscore the promising and compelling potential of targeting the PI3K/Akt signaling pathway and Apoptosis with SZLD as a therapeutic strategy to ameliorate AD.

Keywords

Alzheimer’s disease; Apoptosis; Network pharmacology; Shenzhiling oral liquid.

Figures
Products