2. Academic Validation
  3. A comprehensive analysis-based study of Di-(2-ethylhexyl) phthalate (DEHP)-Environmental explanation of bladder cancer progression

A comprehensive analysis-based study of Di-(2-ethylhexyl) phthalate (DEHP)-Environmental explanation of bladder cancer progression

  • Environ Pollut. 2025 Feb 15:367:125625. doi: 10.1016/j.envpol.2024.125625.
Fei Lin 1,  Wen-Cai Zheng 1,  Zhi-Bin Ke 1,  Dong-Ning Chen 1,  Yu-Ting Xue 1,  Yun-Zhi Lin 1,  Xiao-Dong Li 1,  Qing-Shui Zheng 1,  Yong Wei 1,  Xue-Yi Xue 2,  Ning Xu 3
Affiliations

Affiliations

  • 1 Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Department of Urology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China.
  • 2 Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Department of Urology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Fujian Key Laboratory of Precision Medicine for Cancer, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. Electronic address: xuexueyi@fjmu.edu.cn.
  • 3 Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Department of Urology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, China; Fujian Key Laboratory of Precision Medicine for Cancer, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. Electronic address: drxun@fjmu.edu.cn.
PMID: 39746639 DOI: 10.1016/j.envpol.2024.125625
Abstract

Di-(2-ethylhexyl) phthalate (DEHP) is widely utilized as a plasticizer in industrial manufacturing to enhance the durability and flexibility of plastics. Studies have depicted that DEHP exposure may be associated with multiple cancers, including colorectal, liver and prostate Cancer. However, the effects and underlying mechanisms of DEHP on bladder Cancer progression remain unspecific. In this work, we explored the correlation between DEHP exposure and bladder Cancer through comprehensive analysis. A total of 172 differentially expressed DEHP-related genes (DEDRGs) were screened based on the CTD and TCGA database. In addition, a new prognostic model related to DEHP was developed, which had excellent predictive power for bladder Cancer prognoses. Molecular docking techniques were employed to assess the binding affinity of mono(2-ethylhexyl) phthalate (MEHP) to crucial proteins. Lastly, both in vitro and in vivo experiments, along with RNA Sequencing, were conducted to elucidate the biological roles and mechanisms of MEHP in bladder Cancer. Several new insights into the role of DEHP/MEHP in bladder Cancer were given in this study, as well as an awareness of the association between environmental toxicants and Cancer progression.

Keywords

Bladder cancer; Di-(2-ethylhexyl) phthalate; Molecular docking; Prognosis model.

Figures
Products