2. Academic Validation
  3. Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways

Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways

  • J Cancer. 2025 Jan 1;16(3):765-783. doi: 10.7150/jca.101798.
Qiang Yuan 1 2,  Hangyu Jiang 2 3,  Maofei Zhu 1 2,  Yueming Chu 1 2,  Yan Zhang 1 4,  Jun Bie 5 6,  Lin Li 1 2 6 4
Affiliations

Affiliations

  • 1 Department of Pharmacy, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China, 637003.
  • 2 School of Pharmacy, North Sichuan Medical College, Nanchong, China, 637100.
  • 3 Department of Pharmacy, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China, 637002.
  • 4 Nanchong Key Laboratory of Individualized Drug Therapy, Nanchong, China, 637003.
  • 5 Department of Oncology, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China, 637003.
  • 6 Institute of Tissue Engineering and Stem Cells, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, China, 637003.
PMID: 39781349 DOI: 10.7150/jca.101798
Abstract

Melanoma poses a significant challenge to patients due to its aggressive nature and limited treatment options. Recent studies have suggested that lasalocid, a feed additive ionophore Antibiotic, may have potential as an Anticancer agent. However, the mechanism of lasalocid in melanoma is unclear. This study found that lasalocid could inhibit melanoma cell proliferation, migration, and invasion, while inducing cell cycle arrest and Apoptosis. Transcriptome Sequencing and bioinformatics analysis identified FOXM1 as the hub gene of lasalocid-mediated melanoma treatment. In vitro experiments confirmed that lasalocid regulates FOXM1 expression through the PI3K/Akt and JNK/p38 MAPK pathways. In vivo experiments showed that lasalocid effectively inhibited melanoma growth with acceptable safety. In summary, our study results emphasize lasalocid's potential as a melanoma therapeutic agent and elucidate its role in regulating FOXM1 through the PI3K/Akt and JNK/p38 MAPK pathways.

Keywords

FOXM1; JNK/P38 MAPK signaling pathway; Lasalocid; Melanoma; PI3K/AKT signaling pathway.

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