2. Academic Validation
  3. Effect of long-stranded non-coding RNA-BANCR on the progression of thyroid papillary carcinoma and its mechanism

Effect of long-stranded non-coding RNA-BANCR on the progression of thyroid papillary carcinoma and its mechanism

  • Discov Oncol. 2025 Feb 10;16(1):147. doi: 10.1007/s12672-025-01755-5.
Jiayi Yu # 1,  Kai Hong # 2,  Lingli Yao 3,  Dongbo Shi 3,  Jiabo Zhang 4
Affiliations

Affiliations

  • 1 Medical School, Ningbo University, Ningbo, 315211, Zhejiang, China.
  • 2 Center for Metabolism Medicine, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institute of Medicine, Zhejiang University, Yiwu, 322000, China.
  • 3 Department of Breast Surgery, First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, China.
  • 4 Department of Breast Surgery, First Affiliated Hospital of Ningbo University, Ningbo, 315010, Zhejiang, China. jiaboz_1985@126.com.
  • # Contributed equally.
PMID: 39928209 DOI: 10.1007/s12672-025-01755-5
Abstract

Objective: This study aims to investigate the role of BRAF-activated long non-coding RNA (BANCR) in papillary thyroid carcinoma (PTC) progression and its association with clinical and molecular characteristics.

Methods: Sixteen PTC patients were stratified into four groups (PTC, HT, HT-LNM, and PTC-LNM) based on cervical lymph node metastasis and concurrent Hashimoto's thyroiditis (HT) to explore BANCR expression and its relationship with immune-related factors and tumor microenvironment (TME). Functional assays, including Transwell invasion, colony formation, and CCK8 were performed to evaluate the biological effects of BANCR in PTC cell lines. Bioinformatics analysis further identified BANCR-related pathways and clinical relevance.

Results: BANCR expression was significantly reduced in PTC tissues compared to normal thyroid tissues and was inversely correlated with tumor grade, lymph node metastasis, and T stage. Overexpression of BANCR in PTC cell lines inhibited proliferation, invasion and migration. Bioinformatics analysis demonstrated significant associations between BANCR and immune cell infiltration, immune-related genes, and stromal scores.

Conclusions: BANCR acts as a tumor suppressor in PTC, suppressing tumor growth and metastasis. These findings provide insights into BANCR's potential as a prognostic marker and therapeutic target in PTC.

Keywords

BANCR; Hashimoto's thyroiditis; Long non-coding RNA; Papillary thyroid carcinoma.

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