Interleukin 6 mediated differentiation and rescue of cell redox in PC12 cells exposed to ionizing radiation

FEBS Lett. 1995 May 15;364(3):298-300. doi: 10.1016/0014-5793(95)00412-3.

K Abeyama ¹, K Kawano, T Nakajima, I Takasaki, I Kitajima, I Maruyama

Affiliations

Affiliation

1 Department of Laboratory Medicine, Faculty of Medicine, Kagoshima University, Japan.

PMID: 7538937 DOI: 10.1016/0014-5793(95)00412-3

Abstract

The differentiation of PC12 cells to a neuron-like morphology was induced by ionizing radiation in the presence of serum. This effect was detectable at 5 grays (Gy) and reached a maximum at 10-20 Gy. Increases in the DNA binding activity of nuclear factor kappa B (NF-kappa B) and increased Interleukin 6 (IL-6) mRNA levels were observed at a dose of 15 Gy. Neutralization of supernatant IL-6 by the addition of anti-IL-6 antibody inhibited the neuronal differentiation and decreased cellular redox. Ionizing radiation and serum may act synergistically as neurotropic factors.

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