1. Academic Validation
  2. Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures

Leptosins I and J, cytotoxic substances produced by a Leptosphaeria sp. Physico-chemical properties and structures

  • J Antibiot (Tokyo). 1994 Nov;47(11):1242-9. doi: 10.7164/antibiotics.47.1242.
C Takahashi 1 A Numata E Matsumura K Minoura H Eto T Shingu T Ito T Hasegawa
Affiliations

Affiliation

  • 1 Osaka University of Pharmaceutical Sciences, Japan.
Abstract

Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.

Figures
Products