2. Academic Validation
  3. Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile

Cytotoxic and antimalarial alkaloids from the bulbs of Crinum amabile

  • J Nat Prod. 1993 Aug;56(8):1331-8. doi: 10.1021/np50098a017.
K Likhitwitayawuid 1,  C K Angerhofer,  H Chai,  J M Pezzuto,  G A Cordell,  N Ruangrungsi
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, Chicago 60612.
PMID: 8229016 DOI: 10.1021/np50098a017
Abstract

From the bulbs of Crinum amabile (Amaryllidaceae), a new alkaloid (-)-amabiline [1], together with the known Alkaloids (-)-lycorine [2], (-)-buphanisine [3], (-)-augustine [4], and (+)-crinamine [5], were isolated. The structural characterization of 1 and the revised 1H- and 13C-nmr assignments of 2 are discussed. Alkaloids 2, 4, and 5 were found to be the principal cytotoxic and antimalarial constituents.

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