2. Academic Validation
  3. Two new cytotoxic chalcones from Calythropsis aurea

Two new cytotoxic chalcones from Calythropsis aurea

  • J Nat Prod. 1993 Oct;56(10):1718-22. doi: 10.1021/np50100a009.
J A Beutler 1,  J H Cardellina 2nd,  G N Gray,  T R Prather,  R H Shoemaker,  M R Boyd,  C M Lin,  E Hamel,  G M Cragg
Affiliations

Affiliation

  • 1 Laboratory of Drug Discovery Research & Development, National Cancer Institute, Frederick, Maryland 21702-1201.
PMID: 8277311 DOI: 10.1021/np50100a009
Abstract

The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Cytotoxicity-guided fractionation led to the isolation of two new Chalcones, calythropsin [1] and dihydrocalythropsin [2], which were responsible for the activity. Calythropsin was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.

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