2. Academic Validation
  3. Rumbrin, a new cytoprotective substance produced by Auxarthron umbrinum. I. Taxonomy, production, isolation and biological activities

Rumbrin, a new cytoprotective substance produced by Auxarthron umbrinum. I. Taxonomy, production, isolation and biological activities

  • J Antibiot (Tokyo). 1993 Jun;46(6):884-7. doi: 10.7164/antibiotics.46.884.
Y Yamagishi 1,  M Matsuoka,  A Odagawa,  S Kato,  K Shindo,  J Mochizuki
Affiliations

Affiliation

  • 1 Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
PMID: 8344868 DOI: 10.7164/antibiotics.46.884
Abstract

Rumbrin has been isolated from a fungus, Auxarthron umbrinum, by a screening program designed to find microorganism-produced cytoprotective substances. It was purified by use of column chromatography on silica gel, reversed phase HPLC and then isolated as fine red needles. Rumbrin prevented cell death caused by calcium overload and exhibited a potent inhibitory activity against lipid peroxidation.

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