1. Academic Validation
  2. Enhancement of lithium elimination by multiple-dose sodium polystyrene sulfonate

Enhancement of lithium elimination by multiple-dose sodium polystyrene sulfonate

  • Acad Emerg Med. 1997 Mar;4(3):175-8. doi: 10.1111/j.1553-2712.1997.tb03736.x.
J G Linakis 1 K M Hull P G Lacouture G R Lockhart W J Lewander T J Maher
Affiliations

Affiliation

  • 1 Department of Pediatrics, Rhode Island Hospital, Providence 02903, USA. james-linakis-phd@brown.edu
Abstract

Objective: To determine whether multiple doses of sodium polystyrene sulfonate (SPS) enhance the elimination of IV-administered lithium (Li).

Methods: The study was a placebo-controlled, investigator-unblinded, murine trial of multiple doses of SPS on serum Li concentrations. Seventy-five male CD-1 mice were given IV pretreatment with LiCl (125 mg/ kg) followed by gavage treatments with SPS (5 g/kg/dose) 20, 40, 90, 150, and 210 minutes after LiCl (experimental group) or deionized water at equivalent times (control group). Subgroups of each treatment group were sacrificed at 1, 2, 4, and 6 hours after LiCl administration and blood was collected for Li analysis.

Results: Statistical analyses indicated that the SPS group had lower serum Li concentrations overall than did the control Animals. This difference was apparent at the 2-, 4-, and 6-hour time points.

Conclusion: In this murine model, repetitive doses of orogastric SPS enhanced the elimination of parenterally administered Li.

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Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-148162
    Plasma Potassium Inhibitor