1. Academic Validation
  2. Nocardicyclins A and B: new anthracycline antibiotics produced by Nocardia pseudobrasiliensis

Nocardicyclins A and B: new anthracycline antibiotics produced by Nocardia pseudobrasiliensis

  • J Antibiot (Tokyo). 1997 Oct;50(10):822-7. doi: 10.7164/antibiotics.50.822.
Y Tanaka 1 U Gräfe K Yazawa Y Mikami M Ritzau
Affiliations

Affiliation

  • 1 Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Abstract

Nocardicyclins A (1) and B (2), new anthracycline Antibiotics have been isolated from the mycelial cake of Nocardia pseudobrasiliensis IFM 0624 (JCM 9894). The molecular formulae of 1 and 2 have been determined as C30H35NO11 and C32H37NO12, respectively, and the structures were characterized by 1- and 8-methoxyl groups, a 10-carbonyl group and a novel carbon-methylated aminosugar constituent. Nocardicyclin A (1) exerts cytotoxic activity against L1210 and P388 leukemia. Nocardicyclins A (1) and B (2) are active against Gram-positive bacteria including Mycobacterium spp. and Nocardia spp., but inactive against Gram-negative bacteria.

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