2. Academic Validation
  3. Chronic toxicity studies of piperonyl butoxide in CD-1 mice: induction of hepatocellular carcinoma

Chronic toxicity studies of piperonyl butoxide in CD-1 mice: induction of hepatocellular carcinoma

  • Toxicology. 1997 Dec 26;124(2):95-103. doi: 10.1016/s0300-483x(97)00136-4.
O Takahashi 1,  S Oishi,  T Fujitani,  T Tanaka,  M Yoneyama
Affiliations

Affiliation

  • 1 Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
PMID: 9457999 DOI: 10.1016/s0300-483x(97)00136-4
Abstract

Male and female CD-1 mice (51-104 mice/group) were administered piperonyl butoxide (alpha-[2-(2-butoxyethoxy)ethoxy-4,5-methylenedioxy-2-propyltol uene) in the diet at levels of 0 (control), 0.6 and 1.2% for 52 weeks (1 year). Hepatocellular carcinomas were induced in treated groups in a dose-dependent manner. The incidences of hepatocellular carcinoma were 11.3 and 52.0% in male mice given 0.6 and 1.2% piperonyl butoxide, and 41.2% in female mice given 1.2%. Piperonyl butoxide is thus a hepatocarcinogen to mice as it is known to be to rats.

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