2. Academic Validation
  3. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel

  • Science. 1998 Dec 4;282(5395):1890-3. doi: 10.1126/science.282.5395.1890.
H S Wang 1,  Z Pan,  W Shi,  B S Brown,  R S Wymore,  I S Cohen,  J E Dixon,  D McKinnon
Affiliations

Affiliation

  • 1 Institute of Molecular Cardiology, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.
PMID: 9836639 DOI: 10.1126/science.282.5395.1890
Abstract

The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

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