2. Academic Validation
  3. The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins

The synthesis and evaluation of benzannelated-azatoxins: the benzazatoxins

  • Bioorg Med Chem Lett. 1998 May 5;8(9):1065-70. doi: 10.1016/s0960-894x(98)00176-0.
T A Miller 1,  P R Vachaspati,  M A Labroli,  C D Thompson,  A L Bulman,  T L Macdonald
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Virginia, Charlottesville 22902, USA.
PMID: 9871709 DOI: 10.1016/s0960-894x(98)00176-0
Abstract

The synthesis and evaluation of azatoxin congeners possessing annealed aromatic frameworks are described. The compounds were evaluated for their abilities to affect Topoisomerase II inhibition through the stabilization of "cleavable complex" and for the inhibition of tubulin polymerization using purified bovine brain tubulin.

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