2. PROTAC Immunology/Inflammation
  3. PROTACs Macrophage migration inhibitory factor (MIF)
  4. MD13

MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research.

For research use only. We do not sell to patients.

MD13 Chemical Structure

MD13 Chemical Structure

CAS No. : 2758431-97-7

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Based on 1 publication(s) in Google Scholar

MD13 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a Ki of 71 nM. MD13 can be used for cancer research[1].

IC50 & Target

Ki: 71 nM (MIF)[1]
In Vitro

MD13 degrades 91±5% and 71±7% MIF at 2 μM and 0.2 μM, respectively. MD13 induces MIF degradation through binding to E3 ligase cereblon[1].
MD13 (0-20 μM; 72 h) inhibits cell proliferation of A549 cancer cells[1].
MD13 (1-5 μM; 48 h) arrests cell cycle at G2/M phase in A549 cells[1].
MD13 (2 μM; 6-48 h) inhibits ERK signaling[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MD13 Related Antibodies

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0-20 μM
Incubation Time: 12 h
Result: Caused depletion of MIF protein.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 2 μM
Incubation Time: 6, 24 or 48 h
Result: Inhibited ERK phosphorylation.

Cell Proliferation Assay[1]

Cell Line: A549 cells
Concentration: 0-20 μM
Incubation Time: 72 h
Result: Inhibited the growth of A549 cells in a dose-dependent manner. The inhibitory effect reached about 50% inhibition of cell proliferation at a concentration of 20 µM.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 1, 2, or 5 μM
Incubation Time: 48 h
Result: Dose-dependently induced cell cycle arrest at the G2/M phase.
Molecular Weight

653.68

Formula

C35H35N5O8
CAS No.
SMILES

O=C(NC1=CC=C(N2C(OC3=CC(O)=CC=C3C2)=O)C=C1)CCCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MD13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MD132758431-97-7MD 13MD-13PROTACsMacrophage migration inhibitory factor (MIF)A549MIFmacrophage migration inhibitory factoranticancerERK signalingInhibitorinhibitorinhibit

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