MDL 101146

Cat. No.: HY-117668: FAQs
Data Sheet Handling Instructions

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MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a K_i value of 25 nM. MDL 101146 can be used for the research of arthritis.

For research use only. We do not sell to patients.

MDL 101146 Chemical Structure

CAS No. : 149859-17-6

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Description

IC₅₀ & Target

Ki for neutrophil elastase: 25 nM (human); 18 nM (rat)^[1]^[2]

In Vitro

MDL 101,146 inhibits human neutrophil elastase with a K_i value of 25 nM^[1].
MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a K_i value of 18 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[2]
Dosage:	200 mg/kg
Administration:	Oral, 200 mg/kg/day
Result:	Inhibited the severity of collagen-induced arthritis. Had a bone and cartilage sparing effect in the tibio-tarsal joint of animals with collagen-induced arthritis.

Molecular Weight

632.62

Formula

C₂₉H₃₇F₅N₄O₆

CAS No.

149859-17-6

SMILES

O=C(N(CCC1)[C@@H]1C(NC(C(C)C)C(C(F)(F)C(F)(F)F)=O)=O)[C@H](C(C)C)NC(C(C=C2)=CC=C2C(N3CCOCC3)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl [Content Brief]

[2]. M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46(12):503-8. [Content Brief]

MDL 101146 Related Classifications

Inflammation/Immunology Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDL 101146149859-17-6MDL101146MDL-101146Elastaseoralneutrophil elastasearthritiscartilage degradationInhibitorinhibitorinhibit

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