2. Anti-infection
  3. Bacterial
  4. MDP1 acetate

MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

MDP1 acetate Chemical Structure

MDP1 acetate Chemical Structure

Size Price Stock Quantity
1 mg USD 56 In-stock
5 mg USD 140 In-stock
10 mg USD 225 In-stock
25 mg USD 450 In-stock
50 mg USD 720 In-stock
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200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of MDP1 acetate:

MDP1 acetate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa[1].

In Vitro

MDP1 acetate exhibits more potent antibacterial activities against S. aureus, E. coli and P. aeruginosa.
Geometric means of MICs for MDP1 is recorded at 4.06 μg/mL (S. aureus), 1.22 μg/mL (E. coli) and 3.75 μg/mL (P. aeruginosa), respectively[1].
DNA and calcein release and flow cytometry assays indicate a time-dependent antibacterial activity on the examined bacteria affected by MDP1 (10, 5, 2.5, 1.25, 0.625 and 0.312 μg/mL) acetate. Finally, SEM analyses highlights dose- and time-dependent effects of MDP1 acetate on S. aureus and E. coli bacteria by induction of vesicle or pore formation as well as cell lysis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDP1 acetate Related Antibodies
Molecular Weight

2521.05

Formula

C113H206N34O30
Appearance

Solid

Color

White to off-white

Sequence Shortening

GIGAVLKVLTTGLPALIKRKRQQ
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (3.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3967 mL 1.9833 mL 3.9666 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (19.83 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3967 mL 1.9833 mL 3.9666 mL 9.9165 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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MDP1 acetate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDP1MDP 1MDP-1BacterialantibacterialpeptideMDRmembranedamagecelllysisInhibitorinhibitorinhibit

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