Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc

Name: Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc
Brand: MedChemExpress
SKU: HY-131087
Rating: 4.5 (1 reviews)

Cat. No.: HY-131087 Purity: 98.84%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc Chemical Structure

CAS No. : 894096-02-7

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Glycosidase Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

748.73

Formula

C₃₈H₄₀N₂O₁₄

CAS No.

894096-02-7

Appearance

Solid

Color

White to light yellow

SMILES

O=C(OC)[C@@H](O1)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC2=CC=C(CO)C=C2NC(CCNC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (166.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3356 mL	6.6780 mL	13.3559 mL
5 mM	0.2671 mL	1.3356 mL	2.6712 mL
10 mM	0.1336 mL	0.6678 mL	1.3356 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.84%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (255 KB) HNMR (297 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3356 mL	6.6780 mL	13.3559 mL	33.3899 mL
	5 mM	0.2671 mL	1.3356 mL	2.6712 mL	6.6780 mL
	10 mM	0.1336 mL	0.6678 mL	1.3356 mL	3.3390 mL
	15 mM	0.0890 mL	0.4452 mL	0.8904 mL	2.2260 mL
	20 mM	0.0668 mL	0.3339 mL	0.6678 mL	1.6695 mL
	25 mM	0.0534 mL	0.2671 mL	0.5342 mL	1.3356 mL
	30 mM	0.0445 mL	0.2226 mL	0.4452 mL	1.1130 mL
	40 mM	0.0334 mL	0.1669 mL	0.3339 mL	0.8347 mL
	50 mM	0.0267 mL	0.1336 mL	0.2671 mL	0.6678 mL
	60 mM	0.0223 mL	0.1113 mL	0.2226 mL	0.5565 mL
	80 mM	0.0167 mL	0.0835 mL	0.1669 mL	0.4174 mL
	100 mM	0.0134 mL	0.0668 mL	0.1336 mL	0.3339 mL