2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Mefatinib

Mefatinib  (Synonyms: Mifanertinib dimaleate)

Cat. No.: HY-152852A Purity: 98.90%
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Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity.

For research use only. We do not sell to patients.

Mefatinib Chemical Structure

Mefatinib Chemical Structure

CAS No. : 1989592-50-8

Size Price Stock Quantity
5 mg USD 280 In-stock
10 mg USD 450 In-stock
25 mg USD 900 In-stock
50 mg USD 1450 In-stock
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200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Mefatinib:

Mefatinib Related Antibodies

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Description

Mefatinib is a potent tyrosine kinase inhibitor with antineoplastic activity[1].

Molecular Weight

698.00

Formula

C29H27ClF3N5O10
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(/C=C\C(O)=O)=O.O=C(NC1=CC2=C(NC3=CC=C(C(Cl)=C3)F)N=CN=C2C=C1OC(F)F)/C=C/CN(C)C.OC(/C=C\C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (143.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4327 mL 7.1633 mL 14.3266 mL
5 mM 0.2865 mL 1.4327 mL 2.8653 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4327 mL 7.1633 mL 14.3266 mL 35.8166 mL
5 mM 0.2865 mL 1.4327 mL 2.8653 mL 7.1633 mL
10 mM 0.1433 mL 0.7163 mL 1.4327 mL 3.5817 mL
15 mM 0.0955 mL 0.4776 mL 0.9551 mL 2.3878 mL
20 mM 0.0716 mL 0.3582 mL 0.7163 mL 1.7908 mL
25 mM 0.0573 mL 0.2865 mL 0.5731 mL 1.4327 mL
30 mM 0.0478 mL 0.2388 mL 0.4776 mL 1.1939 mL
40 mM 0.0358 mL 0.1791 mL 0.3582 mL 0.8954 mL
50 mM 0.0287 mL 0.1433 mL 0.2865 mL 0.7163 mL
60 mM 0.0239 mL 0.1194 mL 0.2388 mL 0.5969 mL
80 mM 0.0179 mL 0.0895 mL 0.1791 mL 0.4477 mL
100 mM 0.0143 mL 0.0716 mL 0.1433 mL 0.3582 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mefatinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mefatinib1989592-50-8Mifanertinib dimaleatec-Met/HGFRInhibitorinhibitorinhibit

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