Meglumine (Excipient) (Synonyms: Methylglucamine (Excipient); Meglumin (Excipient); Methylglucamin (Excipient))

Cat. No.: HY-B0342A: FAQs
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Meglumine (Methylglucamine) (Excipient) is an orally active amino sugar derived from sorbitol. Meglumine (Excipient) has anti-inflammatory and antitumor activity. Meglumine (Excipient) is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide.

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Meglumine (Excipient) Chemical Structure

CAS No. : 6284-40-8

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Other In-stock Forms of Meglumine (Excipient):

Meglumine

Other Forms of Meglumine (Excipient):

Meglumine In-stock

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Description

In Vitro

Meglumine (Excipient) (40 or 80 mM, 24 h; 50 mM, 24 h) dose-dependently reduces the levels of inflammatory factors in THP-1 human myeloid cells and RAW264.7 mouse macrophage cells (Elisa assay)^[2].
Meglumine (Excipient) (0-300 mM, 60 min) dose-dependently increases SNARK expression levels in C2C12 mouse myoblasts^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[4]

Cell Line:	C2C12 mouse myoblasts
Concentration:	0, 10, 30, 100, 300 mM or 200 mM
Incubation Time:	60 min or 0, 10, 30, 60, 120 min
Result:	Increased the levels of SNARK protein in a dose-dependent manner after 60 min and reached a plateau at 30 minutes.

In Vivo

Meglumine (Excipient) (25 or 50 mM; 37.5 mM, taken orally dissolved in water) reduces levels of inflammatory factors and inhibits skin cancer tumor growth in rats and mice^[2].
Meglumine (Excipient) (18 mM, oral gavage) improves muscle function, limits metabolic syndrome, and reduces diabetic complications in type 2 diabetic mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rat^[2]
Dosage:	25 or 50 mM
Administration:	p.o., dissolve in water
Result:	Reduced the isoprostane levels in rats.

Animal Model:	K6/ODC transgenic mice^[2]
Dosage:	37.5 mM
Administration:	p.o., dissolve in water
Result:	Reduced the number of skin tumors and inhibited tumor growth.

Animal Model:	KK.Cg-Ay/J mice^[4]
Dosage:	18 mM
Administration:	p.o., dissolve in water
Result:	Performed better in a glucose tolerance test. Decreased their average fasting levels of glucose and triglyceride levels in both the liver and blood serum.

Molecular Weight

195.21

Formula

C₇H₁₇NO₅

CAS No.

6284-40-8

SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CNC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. de Souza ALR, et al. Meglumine-based supra-amphiphile self-assembled in water as a skin drug delivery system: Influence of unfrozen bound water in the system bioadhesiveness. Colloids Surf B Biointerfaces. 2019 Dec 1;184:110523. [Content Brief]

[2]. Manley K, et al. Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine. J Cell Biochem. 2019 Jul;120(7):12051-12062. [Content Brief]

[3]. Guo R Y, et al. Meglumine promoted one-pot, four-component synthesis of pyranopyrazole derivatives. Tetrahedron, 2013, 69(47): 9931-9938.

[4]. Bravo-Nuevo A, et al. Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes. PLoS One. 2014 Feb 27;9(2):e90031. [Content Brief]

Meglumine (Excipient) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meglumine (Excipient)6284-40-8Methylglucamine (Excipient) Meglumin (Excipient) Methylglucamin (Excipient)Biochemical Assay ReagentsTHP-1RAW264.7K6/ODC transgenic miceAnti-inflammatoryInhibitorinhibitorinhibit

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