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  4. Meglumine

Meglumine  (Synonyms: Methylglucamine; Meglumin; Methylglucamin)

Cat. No.: HY-B0342 Purity: ≥98.0%
COA Handling Instructions

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Meglumine (Methylglucamine) is an orally active amino sugar derived from sorbitol. Meglumine has anti-inflammatory and antitumor activity. Meglumine is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide.

For research use only. We do not sell to patients.

Meglumine Chemical Structure

Meglumine Chemical Structure

CAS No. : 6284-40-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
500 mg USD 60 In-stock
1 g   Get quote  
5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Meglumine:

Meglumine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Meglumine (Methylglucamine) is an orally active amino sugar derived from sorbitol. Meglumine has anti-inflammatory and antitumor activity. Meglumine is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide[1][2][3].

In Vitro

Meglumine (40 or 80 mM, 24 h; 50 mM, 24 h) dose-dependently reduces the levels of inflammatory factors in THP-1 human myeloid cells and RAW264.7 mouse macrophage cells (Elisa assay)[2].
Meglumine (0-300 mM, 60 min) dose-dependently increases SNARK expression levels in C2C12 mouse myoblasts[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Meglumine Related Antibodies

Western Blot Analysis[4]

Cell Line: C2C12 mouse myoblasts
Concentration: 0, 10, 30, 100, 300 mM or 200 mM
Incubation Time: 60 min or 0, 10, 30, 60, 120 min
Result: Increased the levels of SNARK protein in a dose-dependent manner after 60 min and reached a plateau at 30 minutes.
In Vivo

Meglumine (25 or 50 mM; 37.5 mM, taken orally dissolved in water) reduces levels of inflammatory factors and inhibits skin cancer tumor growth in rats and mice[2].
Meglumine (18 mM, oral gavage) improves muscle function, limits metabolic syndrome, and reduces diabetic complications in type 2 diabetic mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rat[2]
Dosage: 25 or 50 mM
Administration: p.o., dissolve in water
Result: Reduced the isoprostane levels in rats.
Animal Model: K6/ODC transgenic mice[2]
Dosage: 37.5 mM
Administration: p.o., dissolve in water
Result: Reduced the number of skin tumors and inhibited tumor growth.
Animal Model: KK.Cg-Ay/J mice[4]
Dosage: 18 mM
Administration: p.o., in drinking water
Result: Performed better in a glucose tolerance test.
Decreased their average fasting levels of glucose and triglyceride levels in both the liver and blood serum.
Clinical Trial
Molecular Weight

195.21

Formula

C7H17NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (256.13 mM; Need ultrasonic)

DMSO : 10 mg/mL (51.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1227 mL 25.6134 mL 51.2269 mL
5 mM 1.0245 mL 5.1227 mL 10.2454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (512.27 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (246 KB) HNMR (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.1227 mL 25.6134 mL 51.2269 mL 128.0672 mL
5 mM 1.0245 mL 5.1227 mL 10.2454 mL 25.6134 mL
10 mM 0.5123 mL 2.5613 mL 5.1227 mL 12.8067 mL
15 mM 0.3415 mL 1.7076 mL 3.4151 mL 8.5378 mL
20 mM 0.2561 mL 1.2807 mL 2.5613 mL 6.4034 mL
25 mM 0.2049 mL 1.0245 mL 2.0491 mL 5.1227 mL
30 mM 0.1708 mL 0.8538 mL 1.7076 mL 4.2689 mL
40 mM 0.1281 mL 0.6403 mL 1.2807 mL 3.2017 mL
50 mM 0.1025 mL 0.5123 mL 1.0245 mL 2.5613 mL
H2O 60 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1345 mL
80 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
100 mM 0.0512 mL 0.2561 mL 0.5123 mL 1.2807 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Meglumine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meglumine6284-40-8Methylglucamine Meglumin MethylglucaminBiochemical Assay ReagentsTHP-1RAW264.7K6/ODC transgenic miceAnti-inflammatoryInhibitorinhibitorinhibit

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