2. GPCR/G Protein Neuronal Signaling
  3. Melatonin Receptor
  4. Melatonin-Tamoxifen Conjugate

Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate composed of Melatonin (HY-B0075) and Tamoxifen (HY-13757A), which is a potent antagonist of ERα (IC50=863 nM). Melatonin-Tamoxifen Conjugate binds to MLT receptor (Ki=3.1 nM) and promotes β-arrestin (EC50=914 nM) and ERK activation (EC50=98 nM) in cells expressing hMT1 receptor. Melatonin-Tamoxifen Conjugate against several common cell lines MCF-7, MDA-MB-231, and HT-1080 with IC50s of 6.8 μM, 6.4 μM, and 1.7 μM, respectively.

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Melatonin-Tamoxifen Conjugate Chemical Structure

Melatonin-Tamoxifen Conjugate Chemical Structure

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Melatonin-Tamoxifen Conjugate Related Antibodies

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Description

Melatonin-Tamoxifen Conjugate (compound 16c) is an anticancer drug conjugate composed of Melatonin (HY-B0075) and Tamoxifen (HY-13757A), which is a potent antagonist of ERα (IC50=863 nM). Melatonin-Tamoxifen Conjugate binds to MLT receptor (Ki=3.1 nM) and promotes β-arrestin (EC50=914 nM) and ERK activation (EC50=98 nM) in cells expressing hMT1 receptor. Melatonin-Tamoxifen Conjugate against several common cell lines MCF-7, MDA-MB-231, and HT-1080 with IC50s of 6.8 μM, 6.4 μM, and 1.7 μM, respectively.

Molecular Weight

742.99

Formula

C47H58N4O4
SMILES

O=C(NCCCOC1=CC2=C(NC=C2CCNC(C)=O)C=C1)CCCCCCN(CCOC3=CC=C(/C(C4=CC=CC=C4)=C(C5=CC=CC=C5)/CC)C=C3)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Melatonin-Tamoxifen Conjugate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melatonin-Tamoxifen ConjugateMelatonin ReceptorInhibitorinhibitorinhibit

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