Melperone-d₄ hydrochloride

Name: Melperone-d 4 hydrochloride
Brand: MedChemExpress
SKU: HY-B2169S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-B2169S2 Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

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Melperone-d₄ (hydrochloride) is the deuterium labeled Melperone. Melperone, a butyrophenone, is an antipsychotic agent used for sleep induction which is frequently prescribed in psychiatric setting[1]. Melperone has been used for a variety of indications, including the treatment of schizophrenia, but also for agitation in the elderly[2].

For research use only. We do not sell to patients.

Melperone-d<sub>4</sub> hydrochloride Chemical Structure

Melperone-d₄ hydrochloride Chemical Structure

CAS No. : 1219798-80-7

Size	Price	Stock	Quantity
500 μg	USD 225	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Melperone-d₄ hydrochloride:

Melperone Get quote

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Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

303.84

Formula

C₁₆H₁₉D₄ClFNO

CAS No.

1219798-80-7

Unlabeled CAS

3575-80-2

Appearance

Solid

Color

White to off-white

SMILES

CC(CC1([2H])[2H])CC([2H])([2H])N1CCCC(C2=CC=C(C=C2)F)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (65.82 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2912 mL	16.4560 mL	32.9121 mL
5 mM	0.6582 mL	3.2912 mL	6.5824 mL
10 mM	0.3291 mL	1.6456 mL	3.2912 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (247 KB) HNMR (1053 KB) RP-HPLC (837 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Hefner G, et al. Melperone but not bisoprolol or metoprolol is a clinically relevant inhibitor of CYP2D6: evidence from a therapeutic drug monitoring survey. J Neural Transm (Vienna). 2015 Nov;122(11):1609-17. [Content Brief]

[3]. Bobo WV, et al. Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics. Hum Psychopharmacol. 2009 Jul;24(5):415-22. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2912 mL	16.4560 mL	32.9121 mL	82.2801 mL
	5 mM	0.6582 mL	3.2912 mL	6.5824 mL	16.4560 mL
	10 mM	0.3291 mL	1.6456 mL	3.2912 mL	8.2280 mL
	15 mM	0.2194 mL	1.0971 mL	2.1941 mL	5.4853 mL
	20 mM	0.1646 mL	0.8228 mL	1.6456 mL	4.1140 mL
	25 mM	0.1316 mL	0.6582 mL	1.3165 mL	3.2912 mL
	30 mM	0.1097 mL	0.5485 mL	1.0971 mL	2.7427 mL
	40 mM	0.0823 mL	0.4114 mL	0.8228 mL	2.0570 mL
	50 mM	0.0658 mL	0.3291 mL	0.6582 mL	1.6456 mL
	60 mM	0.0549 mL	0.2743 mL	0.5485 mL	1.3713 mL