1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. Mepivacaine-d3

Mepivacaine-d3 is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

For research use only. We do not sell to patients.

Mepivacaine-d<sub>3</sub> Chemical Structure

Mepivacaine-d3 Chemical Structure

CAS No. : 1346597-90-7

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Based on 1 publication(s) in Google Scholar

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Description

Mepivacaine-d3 is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

249.37

Formula

C15H19D3N2O

CAS No.
Unlabeled CAS

1722-62-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1N(CCCC1)C([2H])([2H])[2H])NC2=C(C=CC=C2C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 30 mg/mL (120.30 mM)

Ethanol : ≥ 30 mg/mL (120.30 mM)

Ethanol : ≥ 30 mg/mL (120.30 mM)

DMF : ≥ 30 mg/mL (120.30 mM)

DMSO : ≥ 25 mg/mL (100.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 25 mg/mL (100.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol:PBS(pH 7.2) (1:1) : ≥ 0.5 mg/mL (2.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0101 mL 20.0505 mL 40.1011 mL
5 mM 0.8020 mL 4.0101 mL 8.0202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol:PBS(pH 7.2) (1:1) / DMSO / DMSO / DMF / Ethanol / Ethanol / DMF 1 mM 4.0101 mL 20.0505 mL 40.1011 mL 100.2526 mL
DMSO / DMSO / DMF / Ethanol / Ethanol / DMF 5 mM 0.8020 mL 4.0101 mL 8.0202 mL 20.0505 mL
10 mM 0.4010 mL 2.0051 mL 4.0101 mL 10.0253 mL
15 mM 0.2673 mL 1.3367 mL 2.6734 mL 6.6835 mL
20 mM 0.2005 mL 1.0025 mL 2.0051 mL 5.0126 mL
25 mM 0.1604 mL 0.8020 mL 1.6040 mL 4.0101 mL
30 mM 0.1337 mL 0.6684 mL 1.3367 mL 3.3418 mL
40 mM 0.1003 mL 0.5013 mL 1.0025 mL 2.5063 mL
50 mM 0.0802 mL 0.4010 mL 0.8020 mL 2.0051 mL
60 mM 0.0668 mL 0.3342 mL 0.6684 mL 1.6709 mL
80 mM 0.0501 mL 0.2506 mL 0.5013 mL 1.2532 mL
100 mM 0.0401 mL 0.2005 mL 0.4010 mL 1.0025 mL
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Mepivacaine-d3
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HY-B0517S
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