Mepivacaine-d₃

Name: Mepivacaine-d 3
Brand: MedChemExpress
SKU: HY-B0517S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0517S Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Mepivacaine-d₃ is the deuterium labeled Mepivacaine. Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

For research use only. We do not sell to patients.

Mepivacaine-d<sub>3</sub> Chemical Structure

Mepivacaine-d₃ Chemical Structure

CAS No. : 1346597-90-7

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Mepivacaine-d₃:

Mepivacaine Get quote

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•Related Small Molecules:

•Related Proteins:

View All Sodium Channel Isoform Specific Products:

View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

249.37

Formula

C₁₅H₁₉D₃N₂O

CAS No.

1346597-90-7

Unlabeled CAS

1722-62-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1N(CCCC1)C([2H])([2H])[2H])NC2=C(C=CC=C2C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : ≥ 30 mg/mL (120.30 mM)

Ethanol : ≥ 30 mg/mL (120.30 mM)

DMF : ≥ 30 mg/mL (120.30 mM)

DMSO : ≥ 25 mg/mL (100.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol:PBS(pH 7.2) (1:1) : ≥ 0.5 mg/mL (2.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0101 mL	20.0505 mL	40.1011 mL
5 mM	0.8020 mL	4.0101 mL	8.0202 mL
10 mM	0.4010 mL	2.0051 mL	4.0101 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Froehle M, et al. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application. Case Rep Pediatr. 2012;2012:491692. [Content Brief]

[3]. mepivacaine hydrochloride.

[4]. Burm, A.G., et al., Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers. Anesth Analg, 1997. 84(1): p. 85-9. [Content Brief]

[5]. Leffler, A., J. Reckzeh, and C. Nau, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol, 2010. 630(1-3): p. 19-28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol:PBS(pH 7.2) (1:1) / DMSO / DMSO / DMF / Ethanol / Ethanol / DMF	1 mM	4.0101 mL	20.0505 mL	40.1011 mL	100.2526 mL
DMSO / DMSO / DMF / Ethanol / Ethanol / DMF	5 mM	0.8020 mL	4.0101 mL	8.0202 mL	20.0505 mL
	10 mM	0.4010 mL	2.0051 mL	4.0101 mL	10.0253 mL
	15 mM	0.2673 mL	1.3367 mL	2.6734 mL	6.6835 mL
	20 mM	0.2005 mL	1.0025 mL	2.0051 mL	5.0126 mL
	25 mM	0.1604 mL	0.8020 mL	1.6040 mL	4.0101 mL
	30 mM	0.1337 mL	0.6684 mL	1.3367 mL	3.3418 mL
	40 mM	0.1003 mL	0.5013 mL	1.0025 mL	2.5063 mL
	50 mM	0.0802 mL	0.4010 mL	0.8020 mL	2.0051 mL
	60 mM	0.0668 mL	0.3342 mL	0.6684 mL	1.6709 mL
	80 mM	0.0501 mL	0.2506 mL	0.5013 mL	1.2532 mL
	100 mM	0.0401 mL	0.2005 mL	0.4010 mL	1.0025 mL