Metapramine  (Synonyms: 19560 RP)

Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds^[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine^[1][2][3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel^[4].

NMDA receptor complex channel^[4]

Metapramine (19560 RP) (0-20 mg/kg; i.p.) shows analgesic effects in mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

238.33

C₁₆H₁₈N₂

21730-16-5

CNC1C2=CC=CC=C2N(C)C3=C(C=CC=C3)C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23.  [Content Brief]

  [2]. M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23.

  [3]. H Dagonneau, et al. [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8.  [Content Brief]

  [4]. J M Warter, et al. Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(2):261-70.  [Content Brief]

  [5]. A Boireau, et al. The antidepressant metapramine is a low-affinity antagonist at N-methyl-D-aspartic acid receptors. Neuropharmacology. 1996;35(12):1703-7.  [Content Brief]

  [6]. Adina Michael-Titus, et al. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain. 1987 Dec;31(3):391-400. doi: 10.1016/0304-3959(87)90167-9.  [Content Brief]