2. Anti-infection Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. Antibiotic Bacterial Histamine Receptor
  4. Methdilazine

Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases.

For research use only. We do not sell to patients.

Methdilazine Chemical Structure

Methdilazine Chemical Structure

CAS No. : 1982-37-2

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Methdilazine Related Antibodies

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Description

Methdilazine is an orally active antibiotic (histamine antagonist). Methdilazine can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2].

IC50 & Target

MIC: 5-15 μg/mL (mycobacterium)
In Vitro

Methdilazine (0-20 μg/mL approximately, 18 h) inhibits kinds of mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methdilazine Related Antibodies

Cell Proliferation Assay[1]

Cell Line: mycobacterium: M. smegmatis 798/1546, M.,fortuitum 1529, M. scrofulaceum 1323, M. gordonae 1324, M. rnarinum 50, M.,flavescens 1541, M. terrae 1450, M. tuberculosis, H37Ra 16, H37Rv 16, K1, K2, ICRC bacillus,'Skinsnes' bacillus.
Concentration: 0-20 μg/mL approximately
Incubation Time: 18 h
Result: Inhibited mycobacterium with MIC values ranging from 5 μg/mL to 15 μg/mL.
In Vivo

Methdilazine (Intraperitoneal injection, 10 μg/gm body wt/day, 6 weeks) is antagonistic to mycobacteria in H37Rv infected mice[1].
Methdilazine (Oral administration, 10 mg/kg per day, 28 days) improves survival of Mycobacterium Tuberculosis (Mtb) H37Rv infected mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: H37Rv infected mice[1]
Dosage: 10 μg/gm body wt/day, 6 weeks
Administration: Intraperitoneal injection
Result: Displayed an anti-mycobacterial activity to mycobacteria.
Animal Model: Mycobacterium Tuberculosis (Mtb) H37Rv infected Swiss albino male mice[2]
Dosage: 10 mg/kg per day for 28 days
Administration: Oral administration
Result: Increased surviving time to 28 days with no sign of disease, showed 71.42% survival.
Molecular Weight

296.43

Formula

C18H20N2S
CAS No.
SMILES

CN1CC(CN2C3=C(C=CC=C3)SC4=CC=CC=C24)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Methdilazine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methdilazine1982-37-2AntibioticBacterialHistamine ReceptorMycobacteriosisMycobacterium Tuberculosis (Mtb)cholinergic antagonistH37Rv infected mice.Inhibitorinhibitorinhibit

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