Methyl azetidine-3-carboxylate hydrochloride

Name: Methyl azetidine-3-carboxylate hydrochloride
Brand: MedChemExpress
SKU: HY-33615
Rating: 4.5 (1 reviews)

Cat. No.: HY-33615 Purity: 99.66%: FAQs
Data Sheet SDS COA Handling Instructions

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Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<

For research use only. We do not sell to patients.

Methyl azetidine-3-carboxylate hydrochloride Chemical Structure

CAS No. : 100202-39-9

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Free Sample (0.1 - 0.5 mg)		Apply Now
1 g	USD 30	In-stock	Estimated Time of Arrival: December 31
5 g	USD 70	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Non-cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

151.59

Formula

C₅H₁₀ClNO₂

CAS No.

100202-39-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CNC1)OC.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (824.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5967 mL	32.9837 mL	65.9674 mL
5 mM	1.3193 mL	6.5967 mL	13.1935 mL
10 mM	0.6597 mL	3.2984 mL	6.5967 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.66%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (249 KB) HNMR (223 KB) RP-HPLC (197 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5967 mL	32.9837 mL	65.9674 mL	164.9185 mL
	5 mM	1.3193 mL	6.5967 mL	13.1935 mL	32.9837 mL
	10 mM	0.6597 mL	3.2984 mL	6.5967 mL	16.4919 mL
	15 mM	0.4398 mL	2.1989 mL	4.3978 mL	10.9946 mL
	20 mM	0.3298 mL	1.6492 mL	3.2984 mL	8.2459 mL
	25 mM	0.2639 mL	1.3193 mL	2.6387 mL	6.5967 mL
	30 mM	0.2199 mL	1.0995 mL	2.1989 mL	5.4973 mL
	40 mM	0.1649 mL	0.8246 mL	1.6492 mL	4.1230 mL
	50 mM	0.1319 mL	0.6597 mL	1.3193 mL	3.2984 mL
	60 mM	0.1099 mL	0.5497 mL	1.0995 mL	2.7486 mL
	80 mM	0.0825 mL	0.4123 mL	0.8246 mL	2.0615 mL
	100 mM	0.0660 mL	0.3298 mL	0.6597 mL	1.6492 mL