Methyl brevifolincarboxylate (Synonyms: Brevifolincarboxylic acid methyl ester)

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Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor. Methyl brevifolincarboxylate has anti-oxidant activity. Methyl brevifolincarboxylate also inhibits platelet aggregation, lipid metabolism and inflammation.

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Methyl brevifolincarboxylate Chemical Structure

CAS No. : 154702-76-8

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
Erythrocyte	IC₅₀	1.04 mM Compound: 13	Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me	[PMID: 29631958]
Erythrocyte	IC₅₀	1.26 mM Compound: 13	Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet	[PMID: 29631958]

In Vitro

Methyl brevifolincarboxylate exhibits significant DPPH radical scavenging activity with an IC₅₀ value of 8.9 μM^[2].
Methyl brevifolincarboxylate (10 and 30 μM) inhibits NO and TNF-α production in LPS stimulated macrophages^[2].
Methyl brevifolincarboxylate (1 and 10 μM) inhibits Norepinephrine (HY-13715)-induced contractions of rat aorta^[3].
Methyl brevifolincarboxylate (5 μM) inhibits platelet aggregation by 73.5%^[4].
Methyl brevifolincarboxylate exhibits inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC₅₀s of 27.16 μM and 33.41 μM^[5].
Methyl brevifolincarboxylate (10-80 μM, 48 h) reduces TG Levels in OA-Treated SK-HEP-1 Cells and Primary Murine Hepatocytes^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[6]

Cell Line:	SK-HEP-1 cells
Concentration:	10, 20, 40, 80 μM
Incubation Time:	48 h
Result:	Reduced the protein levels of FASN, SREBP-1c and ACC1. Increased the expression of PPAR-α.

Molecular Weight

306.22

Formula

C₁₄H₁₀O₈

CAS No.

154702-76-8

SMILES

O=C(C1CC(C2=C1C3=C(O)C(O)=C(O)C=C3C(O2)=O)=O)OC

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu QY, et al. Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography. Int J Mol Sci. 2011;12(12):8740-8749. [Content Brief]

[2]. Fang SH, et al. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J Ethnopharmacol. 2008;116(2):333-340. [Content Brief]

[3]. Iizuka T, et al. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol Pharm Bull. 2006 Jan;29(1):177-9. [Content Brief]

[4]. Iizuka T, et al. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol Pharm Bull. 2007 Feb;30(2):382-4. [Content Brief]

Methyl brevifolincarboxylate Related Classifications

Inflammation/Immunology Infection Cardiovascular Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl brevifolincarboxylate154702-76-8Brevifolincarboxylic acid methyl esterInfluenza VirusMacrophageLPSDPPHNOplateletrat aortaNorepinephrineInhibitorinhibitorinhibit

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