2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Methyl maslinate

Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research.

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Methyl maslinate Chemical Structure

Methyl maslinate Chemical Structure

CAS No. : 22425-82-7

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Based on 1 publication(s) in Google Scholar

Methyl maslinate Related Antibodies

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Description

Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research[1].

Cellular Effect
Cell Line Type Value Description References
518A2 IC50
15.6 μM
Compound: 11
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
[PMID: 24361521]
518A2 IC50
15.6 μM
Compound: 2
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
Cytotoxicity against human 518A2 cells after 96 hrs by SRB assay
[PMID: 24161703]
8505C IC50
14.7 μM
Compound: 11
Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
[PMID: 24361521]
8505C IC50
14.7 μM
Compound: 2
Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
Cytotoxicity against human 8505C cells after 96 hrs by SRB assay
[PMID: 24161703]
A2780 IC50
17.3 μM
Compound: 2
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
[PMID: 24161703]
A2780 IC50
17.8 μM
Compound: 11
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
Cytotoxicity against human A2780 cells after 96 hrs by SRB assay
[PMID: 24361521]
A549 IC50
17.8 μM
Compound: 11
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
[PMID: 24361521]
A549 IC50
17.8 μM
Compound: 2
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
Cytotoxicity against human A549 cells after 96 hrs by SRB assay
[PMID: 24161703]
HT-29 IC50
12.8 μM
Compound: 11
Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
[PMID: 24361521]
HT-29 IC50
12.8 μM
Compound: 2
Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 96 hrs by SRB assay
[PMID: 24161703]
MCF7 IC50
16.3 μM
Compound: 11
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
[PMID: 24361521]
MCF7 IC50
16.3 μM
Compound: 2
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 96 hrs by SRB assay
[PMID: 24161703]
NIH3T3 IC50
21.4 μM
Compound: 11
Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
[PMID: 24361521]
NIH3T3 IC50
21.4 μM
Compound: 2
Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay
[PMID: 24161703]
In Vivo

Methyl maslinate (MM) (20-60 mg/kg; i.p.) shows significant, dose-dependent vasodepressor effect and sinus bradycardia, lasting more than 60 minutes with a maximum at 20 minutes, and shows potent hymodynamic effect[1].
Methyl maslinate (40 mg/kg) shows antidysrhythmic activity on ischemia-reperfusion dysrhythmia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar male rats (300-320 g)[1]
Dosage: 20-60 mg/kg
Administration: Intraperitoneal injection; once
Result: Showed significant, dose-response vasodepressor effect and sinus bradicardia.
Antagonized β-Adrenergic.
Showed antidysrhythmic activity.
Molecular Weight

486.73

Formula

C31H50O4
CAS No.
SMILES

O=C([C@](CC[C@]12C)(CCC3(C)C)[C@](C3)([H])C1=CC[C@@]4([H])[C@]2(CC[C@](C(C)([C@H]5O)C)([H])[C@@]4(C[C@H]5O)C)C)OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Methyl maslinate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl maslinate22425-82-7Adrenergic ReceptorBeta Receptorischemia-reperfusion-induced arrhythmiasantihypertensivecardiotonicantidysrhythmicInhibitorinhibitorinhibit

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