1. PROTAC
  2. PROTAC Linkers
  3. Methylamino-PEG1-Boc

Methylamino-PEG1-Boc  (Synonyms: Methylamino-PEG1-t-butyl ester)

Cat. No.: HY-140154 Purity: ≥95.0%
Data Sheet SDS COA Handling Instructions

Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Methylamino-PEG1-Boc Chemical Structure

Methylamino-PEG1-Boc Chemical Structure

CAS No. : 1807521-03-4

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5 mg USD 40 In-stock
10 mg USD 65 In-stock
25 mg USD 130 In-stock
50 mg USD 200 In-stock
100 mg USD 320 In-stock
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Description

Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

203.28

Formula

C10H21NO3

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCNC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (860.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9193 mL 24.5966 mL 49.1932 mL
5 mM 0.9839 mL 4.9193 mL 9.8386 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9193 mL 24.5966 mL 49.1932 mL 122.9831 mL
5 mM 0.9839 mL 4.9193 mL 9.8386 mL 24.5966 mL
10 mM 0.4919 mL 2.4597 mL 4.9193 mL 12.2983 mL
15 mM 0.3280 mL 1.6398 mL 3.2795 mL 8.1989 mL
20 mM 0.2460 mL 1.2298 mL 2.4597 mL 6.1492 mL
25 mM 0.1968 mL 0.9839 mL 1.9677 mL 4.9193 mL
30 mM 0.1640 mL 0.8199 mL 1.6398 mL 4.0994 mL
40 mM 0.1230 mL 0.6149 mL 1.2298 mL 3.0746 mL
50 mM 0.0984 mL 0.4919 mL 0.9839 mL 2.4597 mL
60 mM 0.0820 mL 0.4099 mL 0.8199 mL 2.0497 mL
80 mM 0.0615 mL 0.3075 mL 0.6149 mL 1.5373 mL
100 mM 0.0492 mL 0.2460 mL 0.4919 mL 1.2298 mL
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Methylamino-PEG1-Boc
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