2. PROTAC
  3. PROTAC Linkers
  4. Methyltetrazine-Ph-NHS ester

Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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Methyltetrazine-Ph-NHS ester Chemical Structure

Methyltetrazine-Ph-NHS ester Chemical Structure

CAS No. : 1644644-96-1

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Based on 1 publication(s) in Google Scholar

Methyltetrazine-Ph-NHS ester Related Antibodies

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Description

Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methyltetrazine-Ph-NHS ester Related Antibodies
Molecular Weight

327.29

Formula

C15H13N5O4
CAS No.
Appearance

Solid

Color

Purple to purplish red

SMILES

O=C(ON1C(CCC1=O)=O)CC2=CC=C(C3=NN=C(C)N=N3)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (305.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0554 mL 15.2770 mL 30.5539 mL
5 mM 0.6111 mL 3.0554 mL 6.1108 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.61%

COA (248 KB) HNMR (257 KB) LCMS (86 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0554 mL 15.2770 mL 30.5539 mL 76.3849 mL
5 mM 0.6111 mL 3.0554 mL 6.1108 mL 15.2770 mL
10 mM 0.3055 mL 1.5277 mL 3.0554 mL 7.6385 mL
15 mM 0.2037 mL 1.0185 mL 2.0369 mL 5.0923 mL
20 mM 0.1528 mL 0.7638 mL 1.5277 mL 3.8192 mL
25 mM 0.1222 mL 0.6111 mL 1.2222 mL 3.0554 mL
30 mM 0.1018 mL 0.5092 mL 1.0185 mL 2.5462 mL
40 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9096 mL
50 mM 0.0611 mL 0.3055 mL 0.6111 mL 1.5277 mL
60 mM 0.0509 mL 0.2546 mL 0.5092 mL 1.2731 mL
80 mM 0.0382 mL 0.1910 mL 0.3819 mL 0.9548 mL
100 mM 0.0306 mL 0.1528 mL 0.3055 mL 0.7638 mL
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Methyltetrazine-Ph-NHS ester Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyltetrazine-Ph-NHS ester1644644-96-1PROTAC LinkersInhibitorinhibitorinhibit

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