2. Anti-infection
  3. SARS-CoV
  4. MI-1851

MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity.

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MI-1851 Chemical Structure

MI-1851 Chemical Structure

CAS No. : 2417283-44-2

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Based on 1 publication(s) in Google Scholar

MI-1851 Related Antibodies

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Description

MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity[1][2].

Cellular Effect
Cell Line Type Value Description References
Vero 76 CC50
> 50 μM
Compound: 8
Cytotoxicity against african green monkey Vero 76 cells by Cell Titer Glo assay
Cytotoxicity against african green monkey Vero 76 cells by Cell Titer Glo assay
[PMID: 33732412]
In Vitro

MI-1851 (0-100 μM, 2h, 24 h) does not affect PHH cells viability, and extracellular hydrogen peroxide production even at 100 μM but reduces CYP3A4 isoenzyme activity in PHH cells in a dose-dependent manner[1].
MI-1851 (10-50 μM, 72 h) strongly inhibits the spread of SARS-CoV-2 and its proliferation in Calu-3 cells even at a low dose of 10 μM, which reduces the virus titer by 30 to 190-fold[2].
MI-1851 (compound 8) (0.5-16 μM, 48 h) inhibits DENV-2 and WNV replication with the EC50 values of 1.50 μM and 1.46 μM, respectively in huh-7 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MI-1851 Related Antibodies
In Vivo
Animal Model: Rats[3]
Dosage: 2.5 mg/kg
Administration: Intravenous injection; once
Result: The pharmacokinetic parameters of MI-1851 (compound 8)
Parameter MI-1851 (compound 8)
t1/2 1.6 h
total body clearance 273 mL/(h•kg)
Cmax 3156 ng/mL
Molecular Weight

767.88

Formula

C34H53N15O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(NCC1=CC=C(C=C1)CC(N[C@H](C(N[C@H](C(N[C@H](C(NCC2=CC=C(C=C2)C(N)=N)=O)CCONC(N)=N)=O)C(C)(C)C)=O)CCONC(N)=N)=O)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (162.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3023 mL 6.5114 mL 13.0229 mL
5 mM 0.2605 mL 1.3023 mL 2.6046 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3023 mL 6.5114 mL 13.0229 mL 32.5572 mL
5 mM 0.2605 mL 1.3023 mL 2.6046 mL 6.5114 mL
10 mM 0.1302 mL 0.6511 mL 1.3023 mL 3.2557 mL
15 mM 0.0868 mL 0.4341 mL 0.8682 mL 2.1705 mL
20 mM 0.0651 mL 0.3256 mL 0.6511 mL 1.6279 mL
25 mM 0.0521 mL 0.2605 mL 0.5209 mL 1.3023 mL
30 mM 0.0434 mL 0.2170 mL 0.4341 mL 1.0852 mL
40 mM 0.0326 mL 0.1628 mL 0.3256 mL 0.8139 mL
50 mM 0.0260 mL 0.1302 mL 0.2605 mL 0.6511 mL
60 mM 0.0217 mL 0.1085 mL 0.2170 mL 0.5426 mL
80 mM 0.0163 mL 0.0814 mL 0.1628 mL 0.4070 mL
100 mM 0.0130 mL 0.0651 mL 0.1302 mL 0.3256 mL
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MI-1851 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI-18512417283-44-2MI1851MI 1851SARS-CoVSARS coronavirusfurin inhibitorSARS-CoV-2antiviralHEK293Inhibitorinhibitorinhibit

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