2. Neuronal Signaling
  3. Glucosylceramide Synthase (GCS)
  4. Miglustat

Miglustat  (Synonyms: N-Butyldeoxynojirimycin; NB-DNJ; OGT 918)

Cat. No.: HY-17020 Purity: ≥98.0%
COA Handling Instructions

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Miglustat (N-Butyldeoxynojirimycin) is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat can be used for the research of type I gaucher disease.

For research use only. We do not sell to patients.

Miglustat Chemical Structure

Miglustat Chemical Structure

CAS No. : 72599-27-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 121 In-stock
Solution
10 mM * 1 mL in Water USD 121 In-stock
Solid
5 mg USD 110 In-stock
10 mg USD 170 In-stock
25 mg USD 330 In-stock
50 mg USD 520 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Miglustat:

Miglustat Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Miglustat (N-Butyldeoxynojirimycin) is an orally active and reversible ceramide glucosyltransferase inhibitor. Miglustat can be used for the research of type I gaucher disease[1].

In Vitro

Miglustat (200 μM; 2, 4 and 24 h) restores F508del-CFTR (cystic fibrosis transmembrane conductance regulator) function in cystic fibrosis (CF) bronchial epithelial IB3-1 and CuFi-1 cells. Miglustat reduces the inflammatory response to P. aeruginosa in both CF and non-CF bronchial cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Miglustat Related Antibodies
In Vivo

Miglustat (0.2 mg/kg; oral administration; once) is able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NPC1−/− mice[1]
Dosage: 0.2 mg/kg
Administration: Oral administration; once
Result: Was able to rescue synaptic plasticity deficits, to restore ERKs activation and to counteract hyperexcitability.
Clinical Trial
Molecular Weight

219.28

Formula

C10H21NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](O)[C@@H](CO)N(CCCC)C[C@@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (1140.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5604 mL 22.8019 mL 45.6038 mL
5 mM 0.9121 mL 4.5604 mL 9.1208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (246 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5604 mL 22.8019 mL 45.6038 mL 114.0095 mL
5 mM 0.9121 mL 4.5604 mL 9.1208 mL 22.8019 mL
10 mM 0.4560 mL 2.2802 mL 4.5604 mL 11.4009 mL
15 mM 0.3040 mL 1.5201 mL 3.0403 mL 7.6006 mL
20 mM 0.2280 mL 1.1401 mL 2.2802 mL 5.7005 mL
25 mM 0.1824 mL 0.9121 mL 1.8242 mL 4.5604 mL
30 mM 0.1520 mL 0.7601 mL 1.5201 mL 3.8003 mL
40 mM 0.1140 mL 0.5700 mL 1.1401 mL 2.8502 mL
50 mM 0.0912 mL 0.4560 mL 0.9121 mL 2.2802 mL
60 mM 0.0760 mL 0.3800 mL 0.7601 mL 1.9002 mL
80 mM 0.0570 mL 0.2850 mL 0.5700 mL 1.4251 mL
100 mM 0.0456 mL 0.2280 mL 0.4560 mL 1.1401 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Miglustat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Miglustat72599-27-0N-Butyldeoxynojirimycin NB-DNJ OGT 918OGT918OGT 918OGT-918Glucosylceramide Synthase (GCS)oralceramide glucosyltransferasetype I gaucher diseaseInhibitorinhibitorinhibit

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