1. Membrane Transporter/Ion Channel Apoptosis
  2. P2X Receptor Apoptosis
  3. Minodronic acid hydrate

Minodronic acid hydrate  (Synonyms: YM-529 hydrate)

Cat. No.: HY-16322A Purity: 99.67%
SDS COA Handling Instructions Technical Support

Minodronic acid (YM-529) hydrate is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain.

For research use only. We do not sell to patients.

Minodronic acid hydrate Chemical Structure

Minodronic acid hydrate Chemical Structure

CAS No. : 155648-60-5

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Based on 1 publication(s) in Google Scholar

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Description

Minodronic acid (YM-529) hydrate is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2].

Molecular Weight

340.16

Formula

C9H14N2O8P2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(P(O)(O)=O)(P(O)(O)=O)CC1=CN=C2C=CC=CN21.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (58.80 mM; ultrasonic and adjust pH to 9 with 1 M NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9398 mL 14.6990 mL 29.3979 mL
5 mM 0.5880 mL 2.9398 mL 5.8796 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9398 mL 14.6990 mL 29.3979 mL 73.4948 mL
5 mM 0.5880 mL 2.9398 mL 5.8796 mL 14.6990 mL
10 mM 0.2940 mL 1.4699 mL 2.9398 mL 7.3495 mL
15 mM 0.1960 mL 0.9799 mL 1.9599 mL 4.8997 mL
20 mM 0.1470 mL 0.7349 mL 1.4699 mL 3.6747 mL
25 mM 0.1176 mL 0.5880 mL 1.1759 mL 2.9398 mL
30 mM 0.0980 mL 0.4900 mL 0.9799 mL 2.4498 mL
40 mM 0.0735 mL 0.3675 mL 0.7349 mL 1.8374 mL
50 mM 0.0588 mL 0.2940 mL 0.5880 mL 1.4699 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Minodronic acid hydrate
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HY-16322A
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