(-)-Antofine

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(-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound.

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(-)-Antofine Chemical Structure

CAS No. : 32671-82-2

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Biological Activity
Purity & Documentation
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Description

(-)-Antofine is an alkaloid, a levorotatory Antofine. Antofine is an antifungal compound^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.008 μM Compound: antofine	Cytotoxicity against human A549 cells by SRB microtiter plate assay Cytotoxicity against human A549 cells by SRB microtiter plate assay	[PMID: 17585747]
A549	GI₅₀	0.01 μM Compound: 5	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 22417638]
A549	IC₅₀	0.022 μM Compound: Antofine	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 28431881]
A549	IC₅₀	0.022 μM Compound: Antofine	Anticancer activity against human A549 cells after 72 hrs by SRB assay Anticancer activity against human A549 cells after 72 hrs by SRB assay	[PMID: 19645447]
A549	IC₅₀	0.022 μM Compound: antofine	Cytotoxicity against human A549 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis Cytotoxicity against human A549 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis	[PMID: 22823514]
A549	IC₅₀	10 nM Compound: (-)-antofine A	Antiproliferative activity against human A549 cells after 72 hrs by ATPlite assay Antiproliferative activity against human A549 cells after 72 hrs by ATPlite assay	[PMID: 25499434]
A549	IC₅₀	10.4 nM Compound: (-)-1	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 17049857]
A549	IC₅₀	11 nM Compound: 1, (-)-Antofine	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 23294831]
A549	IC₅₀	18 nM Compound: 1, (-)-Antofine	Cytotoxicity against human paclitaxel-resistant A549 cells after 72 hrs by SRB assay Cytotoxicity against human paclitaxel-resistant A549 cells after 72 hrs by SRB assay	[PMID: 23294831]
A549	GI₅₀	22 nM Compound: R-antofine	Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay Anticancer activity against human A549 cells after 72 hrs by sulforhodamine B assay	[PMID: 21668000]
A549	IC₅₀	8.52 nM Compound: 1	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
CAKI-1	IC₅₀	6.23 nM Compound: 1	Cytotoxicity against human Caki1 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human Caki1 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
DU-145	IC₅₀	0.009 μM Compound: antofine	Cytotoxicity against human DU145 cells by SRB microtiter plate assay Cytotoxicity against human DU145 cells by SRB microtiter plate assay	[PMID: 17585747]
DU-145	IC₅₀	0.025 μM Compound: Antofine	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 28431881]
DU-145	IC₅₀	0.025 μM Compound: Antofine	Anticancer activity against human DU145 cells after 72 hrs by SRB assay Anticancer activity against human DU145 cells after 72 hrs by SRB assay	[PMID: 19645447]
DU-145	IC₅₀	0.025 μM Compound: antofine	Cytotoxicity against human DU145 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis Cytotoxicity against human DU145 cells after 2 hrs by methylene blue staining-based spectrophotometric analysis	[PMID: 22823514]
DU-145	GI₅₀	25 nM Compound: R-antofine	Anticancer activity against human DU145 cells after 72 hrs by sulforhodamine B assay Anticancer activity against human DU145 cells after 72 hrs by sulforhodamine B assay	[PMID: 21668000]
HCT-116	IC₅₀	6.03 nM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
HCT-116	IC₅₀	8 nM Compound: 1, (-)-Antofine	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 23294831]
HCT-116	IC₅₀	9.9 nM Compound: (-)-1	Cytotoxicity against human HCT116 cells by SRB assay Cytotoxicity against human HCT116 cells by SRB assay	[PMID: 17049857]
HCT-15	IC₅₀	13 nM Compound: 1, (-)-Antofine	Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay Cytotoxicity against human HCT15 cells after 72 hrs by SRB assay	[PMID: 23294831]
HL-60	GI₅₀	< 0.001 μM Compound: 5	Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay Antiproliferative activity against human HL60 cells after 72 hrs by SRB assay	[PMID: 22417638]
HT-1080	IC₅₀	9.6 nM Compound: (-)-1	Cytotoxicity against human HT1080 cells by SRB assay Cytotoxicity against human HT1080 cells by SRB assay	[PMID: 17049857]
KB	IC₅₀	0.013 μM Compound: antofine	Cytotoxicity against human KB cells by SRB microtiter plate assay Cytotoxicity against human KB cells by SRB microtiter plate assay	[PMID: 17585747]
KB	IC₅₀	0.036 μM Compound: Antofine	Anticancer activity against human KB cells after 72 hrs by SRB assay Anticancer activity against human KB cells after 72 hrs by SRB assay	[PMID: 19645447]
KB	IC₅₀	0.036 μM Compound: antofine	Cytotoxicity against human KB cells after 2 hrs by methylene blue staining-based spectrophotometric analysis Cytotoxicity against human KB cells after 2 hrs by methylene blue staining-based spectrophotometric analysis	[PMID: 22823514]
KB	GI₅₀	36 nM Compound: R-antofine	Anticancer activity against human KB cells after 72 hrs by sulforhodamine B assay Anticancer activity against human KB cells after 72 hrs by sulforhodamine B assay	[PMID: 21668000]
KB 3-1	IC₅₀	16 nM Compound: 1, (-)-(R)-13aalpha-antofine	Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay Cytotoxicity against drug-resistant human KB-3-1 cells by MTS/PMS assay	[PMID: 12350151]
KB-V1	IC₅₀	14 nM Compound: 1, (-)-(R)-13aalpha-antofine	Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay Cytotoxicity against multidrug-resistant human KBV1 cells by MTS/PMS assay	[PMID: 12350151]
MDA-MB-231	IC₅₀	0.012 μM Compound: Antofine	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 28431881]
MDA-MB-231	IC₅₀	6.04 nM Compound: 1	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
PC-3	IC₅₀	12.34 nM Compound: 1	Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human PC3 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
SK-HEP1	IC₅₀	6.32 nM Compound: 1	Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human SKHEP1 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
SK-HEP1	IC₅₀	8 nM Compound: 1, (-)-Antofine	Cytotoxicity against human SKHEP1 cells after 72 hrs by SRB assay Cytotoxicity against human SKHEP1 cells after 72 hrs by SRB assay	[PMID: 23294831]
SNU-638	IC₅₀	10 nM Compound: 1, (-)-Antofine	Cytotoxicity against human SNU638 cells after 72 hrs by SRB assay Cytotoxicity against human SNU638 cells after 72 hrs by SRB assay	[PMID: 23294831]
SNU-638	IC₅₀	10.38 nM Compound: 1	Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against human SNU638 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 26393416]
ZR-75-1	IC₅₀	0.008 μM Compound: antofine	Cytotoxicity against human ZR751cells by SRB microtiter plate assay Cytotoxicity against human ZR751cells by SRB microtiter plate assay	[PMID: 17585747]

Molecular Weight

363.45

Formula

C₂₃H₂₅NO₃

CAS No.

32671-82-2

SMILES

COC1=CC=C2C(C3=CC(OC)=C(OC)C=C3C4=C2CN5[C@@](CCC5)([H])C4)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xin Z, et al. Isolation of antofine from Cynanchum atratum BUNGE (Asclepiadaceae) and its antifungal activity against Penicillium digitatum[J]. Postharvest Biology and Technology, 2019, 157: 110961.

(-)-Antofine Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Antofine32671-82-2FungalalkaloidlevorotatoryInhibitorinhibitorinhibit

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