(-)-BO 2367

Cat. No.: HY-117657: FAQs
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(-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC₅₀ values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent.

For research use only. We do not sell to patients.

(-)-BO 2367 Chemical Structure

CAS No. : 145902-81-4

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

Topoisomerase II

Molecular Weight

437.87

Formula

C₂₁H₂₂ClF₂N₃O₃

CAS No.

145902-81-4

SMILES

FC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@]5([H])[C@@](CC=C[C@H]5N)([H])C4)=O)C(O)=O.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. T Yoshinari, et al. Stereo (C7)-dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367. Jpn J Cancer Res. 1993 Jul;84(7):800-6. [Content Brief]

(-)-BO 2367 Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-BO 2367145902-81-4TopoisomeraseBacterialquinolonemammalianbacterialDNA relaxationL1210Escherichia coli gyraseMicrococcus luteus gyraseantitumorInhibitorinhibitorinhibit

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