2. Cell Cycle/DNA Damage Anti-infection
  3. Topoisomerase Bacterial
  4. (-)-BO 2367

(-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent.

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(-)-BO 2367 Chemical Structure

(-)-BO 2367 Chemical Structure

CAS No. : 145902-81-4

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(-)-BO 2367 Related Antibodies

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Description

(-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent[1].

IC50 & Target[1]

Topoisomerase II

 

Molecular Weight

437.87

Formula

C21H22ClF2N3O3
CAS No.
SMILES

FC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@]5([H])[C@@](CC=C[C@H]5N)([H])C4)=O)C(O)=O.Cl
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Purity & Documentation
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(-)-BO 2367 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-BO 2367145902-81-4TopoisomeraseBacterialquinolonemammalianbacterialDNA relaxationL1210Escherichia coli gyraseMicrococcus luteus gyraseantitumorInhibitorinhibitorinhibit

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