(-)-Clerosterol

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(-)-Clerosterol is a natural product that can be isolated from Codium fragile.

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(-)-Clerosterol Chemical Structure

CAS No. : 2364-23-0

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Other Forms of (-)-Clerosterol:

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Biological Activity
Purity & Documentation
References
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Description

(-)-Clerosterol is a natural product that can be isolated from Codium fragile^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	0.3 μg/mL Compound: 1, clerosterol	Cytotoxicity against human A549 cells after 6 days by MTT assay Cytotoxicity against human A549 cells after 6 days by MTT assay	10.1021/np50124a007
HT-29	ED₅₀	43.1 μg/mL Compound: 1, clerosterol	Cytotoxicity against human HT-29 cells after 6 days by MTT assay Cytotoxicity against human HT-29 cells after 6 days by MTT assay	10.1021/np50124a007
J774	IC₅₀	> 242.3 μM Compound: 13	Cytotoxicity against mouse J774 cells by alamar blue assay Cytotoxicity against mouse J774 cells by alamar blue assay	[PMID: 17637068]
KB	ED₅₀	> 50 μg/mL Compound: 1, clerosterol	Cytotoxicity against human KB cells after 3 days by MTT assay Cytotoxicity against human KB cells after 3 days by MTT assay	10.1021/np50124a007
P388	ED₅₀	1.7 μg/mL Compound: 1, clerosterol	Cytotoxicity against mouse P388 cells after 3 days by MTT assay Cytotoxicity against mouse P388 cells after 3 days by MTT assay	10.1021/np50124a007

Molecular Weight

412.69

Formula

C₂₉H₄₈O

CAS No.

2364-23-0

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@H](CC)C(C)=C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C

Structure Classification

Others

Initial Source

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kim AD, et al. Cytotoxic effect of clerosterol isolated from Codium fragile on A2058 human melanoma cells. Mar Drugs. 2013 Feb 6;11(2):418-30. [Content Brief]

(-)-Clerosterol Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(-)-Clerosterol2364-23-0OthersInhibitorinhibitorinhibit

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