2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. (-)-Isodocarpin

(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA.

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(-)-Isodocarpin Chemical Structure

(-)-Isodocarpin Chemical Structure

CAS No. : 10391-08-9

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Based on 1 publication(s) in Google Scholar

(-)-Isodocarpin Related Antibodies

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Description

(-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
3.2 μM
Compound: 14
Cytotoxicity against human A549 cells after 48 hrs by MTS assay
Cytotoxicity against human A549 cells after 48 hrs by MTS assay
[PMID: 24219809]
HL-60 IC50
2.8 μM
Compound: 14
Cytotoxicity against human HL60 cells after 48 hrs by MTS assay
Cytotoxicity against human HL60 cells after 48 hrs by MTS assay
[PMID: 24219809]
MCF7 IC50
2.6 μM
Compound: 14
Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
[PMID: 24219809]
RAW264.7 IC50
2.2 μM
Compound: 14
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay
Inhibition of LPS-stimulated NO production in mouse RAW264.7 cells after 18 hrs by Griess assay
[PMID: 24219809]
SMMC-7721 IC50
3.5 μM
Compound: 14
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay
Cytotoxicity against human SMMC7721 cells after 48 hrs by MTS assay
[PMID: 24219809]
SW480 IC50
1 μM
Compound: 14
Cytotoxicity against human SW480 cells after 48 hrs by MTS assay
Cytotoxicity against human SW480 cells after 48 hrs by MTS assay
[PMID: 24219809]
Molecular Weight

346.42

Formula

C20H26O5
CAS No.
SMILES

O[C@H]1[C@@]2([H])[C@]3(CO1)[C@@]4([H])[C@@]5(C(O[C@@]3([H])CCC2(C)C)=O)C[C@@](C(C5=O)=C)([H])CC4
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(-)-Isodocarpin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Isodocarpin10391-08-9IsodocarpinMelanocortin ReceptorMC ReceptorditerpenoidmelanogenesisB16 4A5 celltyrosinasetyrosine-related proteinTRP-1TRP-2Inhibitorinhibitorinhibit

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