2. PI3K/Akt/mTOR
  3. PI3K
  4. MIPS-9922

MIPS-9922 is a potent and selective PI3Kβ inhibitor with an IC50 of 63 nM. MIPS-9922 inhibits PI3Kβ with >30-fold higher potency than PI3Kδ. MIPS-9922 blocks PI3K mediated activation of platelet glycoprotein αIIbβ3 activation and platelet adhesion in vitro. MIPS-9922 shows anti-platelet and anti-thrombotic activities.

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MIPS-9922 Chemical Structure

MIPS-9922 Chemical Structure

CAS No. : 1416956-33-6

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MIPS-9922 Related Antibodies

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Description

MIPS-9922 is a potent and selective PI3Kβ inhibitor with an IC50 of 63 nM. MIPS-9922 inhibits PI3Kβ with >30-fold higher potency than PI3Kδ. MIPS-9922 blocks PI3K mediated activation of platelet glycoprotein αIIbβ3 activation and platelet adhesion in vitro. MIPS-9922 shows anti-platelet and anti-thrombotic activities[1].

IC50 & Target[1]

PI3Kβ

63 nM (IC50)

PI3Kδ

2200 nM (IC50)

In Vitro

MIPS-9922 potently inhibits ADP-induced washed platelet aggregation. MIPS-9922 also inhibits integrin αIIbβ3 activation and αIIbβ3 dependent platelet adhesion to immobilized von Willebrand Factor (vWF) under high shear[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MIPS-9922 Related Antibodies
In Vivo

MIPS-9922 (2.5 mg/kg, bolus jugular vein injection; once) prevents arterial thrombus formation in the in vivo electrolytic mouse model of thrombosis without inducing prolonged bleeding or excess blood loss[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice bearing electrolytic injury[1]
Dosage: 2.5 mg/kg
Administration: Bolus jugular vein injection; once
Result: Prevented arterial thrombus formation in the in vivo electrolytic mouse model of thrombosis.
Molecular Weight

563.60

Formula

C28H31F2N9O2
CAS No.
SMILES

O=C(N1CCN(C2=NC(N3C4=CC=CC=C4N=C3C(F)F)=NC(N5CCOCC5)=N2)CC1)[C@@H](N)CC6=CC=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MIPS-9922 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MIPS-99221416956-33-6MIPS9922MIPS 9922PI3KPhosphoinositide 3-kinaseAnti-platelet activityplatelet aggregationAnti-thrombotic activityPI3Kβ inhibitorInhibitorinhibitorinhibit

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