2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Mirvetuximab

Mirvetuximab  (Synonyms: M9346A)

Cat. No.: HY-P99225 Purity: 99.88%
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Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research.

For research use only. We do not sell to patients.

CAS No. : 1453084-36-0

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Mirvetuximab Related Antibodies

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Description

Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Chimeric
In Vitro

Mirvetuximab (0.17 pM-81 nM, 2 h) bounds three antibodies bound with high affinity, with EC50 values in the double-digit picomolar range (14.3, 16.5, and 21.1 pM for binding to clones 4E12-G5, 4E12-B9, and 5D12-C11, respectively)[2].
Mirvetuximab (1 pM-100 nM) shows dose-dependent binding to folate receptor in the absence of competing anti-idiotype antibodies[2].
M9346A (1 pM-100 nM) associates with H2110 cells with an EC50 of around 650 pM by specific binding of M9346A to surface folate receptor antigen[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mirvetuximab Related Antibodies
Clinical Trial
Molecular Weight

145200.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Mirvetuximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized FOLR1 Protein, Human (HEK293, His) can bind Mirvetuximab. The EC50 for this effect is 6.576 ng/mL.
Purity & Documentation

Purity: 99.88%

SDS (251 KB)

COA (231 KB) SDS-PAGE (68 KB) SEC-HPLC (128 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Mirvetuximab Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mirvetuximab1453084-36-0M9346AAntifolateFRα-targeting ADCovarianFRα-positive cancerInhibitorinhibitorinhibit

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