MK-4965

Cat. No.: HY-14361: FAQs
Data Sheet Handling Instructions

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MK-4965 is a nonnucleoside reverse transcriptase inhibitor (NNRTI). MK-4965 displays excellent activities against not only HIV-1 wild-type (WT) virus but also against a broad panel of NNRTI-resistant viruses and can be used for the research of HIV-1 infection.

For research use only. We do not sell to patients.

MK-4965 Chemical Structure

CAS No. : 920035-77-4

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

IC50: 0.23 nM (WT), 0.39 nM (Y181C), 0.40 nM (K103N)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against human HL60 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human HL60 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Macrophage	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against activated human macrophage after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human macrophage after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Macrophage	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human macrophage after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human macrophage after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Monocyte	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human monocyte after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human monocyte after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
Monocyte	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against activated human monocyte after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human monocyte after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
MT4	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against human MT4 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human MT4 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
PBMC	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human PBMC after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human PBMC after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
PBMC	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against activated human PBMC after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human PBMC after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
SUP-T1	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against human SupT1 cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against human SupT1 cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
T-cell	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against activated human CD4+ T cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against activated human CD4+ T cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]
T-cell	EC₅₀	> 3 μM Compound: MK-4965	Cytotoxicity against stationary-phase human CD4+ T cells after 24 to 72 hrs by alamar blue assay Cytotoxicity against stationary-phase human CD4+ T cells after 24 to 72 hrs by alamar blue assay	[PMID: 19289522]

Molecular Weight

426.26

Formula

C₂₀H₁₃Cl₂N₅O₂

CAS No.

920035-77-4

SMILES

N#CC1=CC(Cl)=CC(OC2=CC(OCC3=NNC4=NC(N)=CC=C43)=CC=C2Cl)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lai MT, et al. Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2009 Jun;53(6):2424-31. [Content Brief]

MK-4965 Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-4965920035-77-4MK4965MK 4965HIVReverse TranscriptaseHuman immunodeficiency virusK103NY181CNNRTIInhibitorinhibitorinhibit

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