1. Metabolic Enzyme/Protease
  2. Renin
  3. MK-8141

MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.

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MK-8141 Chemical Structure

MK-8141 Chemical Structure

CAS No. : 903579-36-2

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Description

MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition.

Molecular Weight

620.61

Formula

C35H39Cl2N3O3

CAS No.
SMILES

O=C(C1=C(C2=CC=C(OCCOC3=C(Cl)C=C(C)C=C3Cl)C=C2)C[C@]4([H])CNC[C@@]1([H])N4)N(C5CC5)CC6=CC=CC(C)=C6C

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Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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MK-8141 Related Classifications

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Product Name:
MK-8141
Cat. No.:
HY-12172
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