MKA031

Cat. No.: HY-149308: FAQs
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MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC₅₀ value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection.

For research use only. We do not sell to patients.

MKA031 Chemical Structure

CAS No. : 2951012-00-1

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Description

In Vitro

MKA031 (compound 6y) (1-100 μl; 3 h) prevents MNNG-Induced Cell Death^[1]. MKA031 (compound 6y) (100 μl;3 h) protects Genomic DNA by Blocking the Recruitment of MIF to AIF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Hela cells
Concentration:	1-100 μM
Incubation Time:	3 h
Result:	Protected HeLa cells from MNNG-induced parthanatos in a dose dependent manner with an EC₅₀ of 7.7 μM.

Immunofluorescence^[1]

Cell Line:	Hela cells
Concentration:	100 μM
Incubation Time:	3 h
Result:	Interfered with the MIF/AIF interaction and blocks MIF nuclear translocation.

Molecular Weight

403.46

Formula

C₂₁H₁₇N₅O₂S

CAS No.

2951012-00-1

SMILES

O=C(NC1=CC=CC=C1)C2=CC=C(C=C2)N3N=NC(C(NCC4=CC=CS4)=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen D, et al. Allosteric Inhibitors of Macrophage Migration Inhibitory Factor (MIF) Interfere with Apoptosis-Inducing Factor (AIF) Co-Localization to Prevent Parthanatos. J Med Chem. 2023 Jul 13;66(13):8767-8781. [Content Brief]

MKA031 Related Classifications

Infection

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MKA0312951012-00-1MKA 031MKA-031Macrophage migration inhibitory factor (MIF)Hepatitis CMNNGMIF/AIFparthanatosInhibitorinhibitorinhibit

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