2. GPCR/G Protein Neuronal Signaling
  3. GPR55
  4. ML191

ML-191 is an antagonist of GPR55. It inhibits GPR55 signaling induced by lysophosphatidylinositol (EC50=1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50=328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 µM.

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ML191 Chemical Structure

ML191 Chemical Structure

CAS No. : 931695-79-3

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10 mg USD 145 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ML-191 is an antagonist of GPR55. It inhibits GPR55 signaling induced by lysophosphatidylinositol (EC50=1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50=328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 µM[1].

Cellular Effect
Cell Line Type Value Description References
U2OS IC50
1.1 μM
Compound: ML191; CID 23612552
Antagonist activity at HA-epitope tagged GRP55E expressed with GFP-tagged beta-arr2 in human U2OS cells assessed as LPI-stimulated redistribution of beta-arr2 preincubated for 15 mins by beta-arrestin translocation assay
Antagonist activity at HA-epitope tagged GRP55E expressed with GFP-tagged beta-arr2 in human U2OS cells assessed as LPI-stimulated redistribution of beta-arr2 preincubated for 15 mins by beta-arrestin translocation assay
[PMID: 26916440]
Molecular Weight

403.47

Formula

C24H25N3O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1OC(C2=CC=CC=C2)=NN1C3CCN(C(C4(C5=CC=C(C)C=C5)CC4)=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (309.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4785 mL 12.3925 mL 24.7850 mL
5 mM 0.4957 mL 2.4785 mL 4.9570 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4785 mL 12.3925 mL 24.7850 mL 61.9625 mL
5 mM 0.4957 mL 2.4785 mL 4.9570 mL 12.3925 mL
10 mM 0.2478 mL 1.2392 mL 2.4785 mL 6.1962 mL
15 mM 0.1652 mL 0.8262 mL 1.6523 mL 4.1308 mL
20 mM 0.1239 mL 0.6196 mL 1.2392 mL 3.0981 mL
25 mM 0.0991 mL 0.4957 mL 0.9914 mL 2.4785 mL
30 mM 0.0826 mL 0.4131 mL 0.8262 mL 2.0654 mL
40 mM 0.0620 mL 0.3098 mL 0.6196 mL 1.5491 mL
50 mM 0.0496 mL 0.2478 mL 0.4957 mL 1.2392 mL
60 mM 0.0413 mL 0.2065 mL 0.4131 mL 1.0327 mL
80 mM 0.0310 mL 0.1549 mL 0.3098 mL 0.7745 mL
100 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6196 mL
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ML191 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML191931695-79-3CID23612552ML 191ML-191CID 23612552CID-23612552GPR55G protein-coupled receptor 55Inhibitorinhibitorinhibit

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