2. Metabolic Enzyme/Protease
  3. Glucosidase
  4. ML198

ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease. ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

ML198 Chemical Structure

ML198 Chemical Structure

CAS No. : 1380716-06-2

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Based on 1 publication(s) in Google Scholar

ML198 Related Antibodies

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Description

ML198 is a glucocerebrosidase (GCase) modulator with an EC50 of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease[1]. ML198 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

EC50: 0.4 μM (glucocerebrosidase)[1]
In Vitro

ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr[1].
ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 µM, compared to 5% of DMSO) in human fibroblasts[1].
ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ML198 Related Antibodies
Molecular Weight

290.32

Formula

C17H14N4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=C(C=C1)C#C)C2=C3N=C(C=C(N3N=C2)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (17.22 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4445 mL 17.2224 mL 34.4447 mL
5 mM 0.6889 mL 3.4445 mL 6.8889 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4445 mL 17.2224 mL 34.4447 mL 86.1119 mL
5 mM 0.6889 mL 3.4445 mL 6.8889 mL 17.2224 mL
10 mM 0.3444 mL 1.7222 mL 3.4445 mL 8.6112 mL
15 mM 0.2296 mL 1.1482 mL 2.2963 mL 5.7408 mL
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ML198 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML1981380716-06-2ML 198ML-198GlucosidaseGlucocerebrosidaseGCase modulatorGaucher diseaseNon-inhibitory chaperoneInhibitorinhibitorinhibit

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