2. Peptides
  3. Peptide and Derivatives
  4. Inhibitors and Substrates
  5. mLR12

mLR12 is a Trem1 inhibitory peptide. mLR12 decreases aortic rupture rate in BAPN-induced Thoracic aortic aneurysm and dissection (TAAD) mice model.

For research use only. We do not sell to patients.

mLR12 Chemical Structure

mLR12 Chemical Structure

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1 mg USD 50 In-stock
5 mg USD 125 In-stock
10 mg USD 200 In-stock
25 mg USD 330 In-stock
50 mg USD 500 In-stock
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Based on 1 publication(s) in Google Scholar

mLR12 Related Antibodies

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Description

mLR12 is a Trem1 inhibitory peptide. mLR12 decreases aortic rupture rate in BAPN-induced Thoracic aortic aneurysm and dissection (TAAD) mice model[1].

Molecular Weight

1341.40

Formula

C55H84N14O23S
Appearance

Solid

Color

White to off-white

Sequence

Leu-Gln-Glu-Glu-Asp-Thr-Gly-Glu-Tyr-Gly-Cys-Val-NH2
Sequence Shortening

LQEEDTGEYGCV-NH2
SMILES

O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(N[C@@H](CS)C(N[C@@H](C(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (74.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7455 mL 3.7274 mL 7.4549 mL
5 mM 0.1491 mL 0.7455 mL 1.4910 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7455 mL 3.7274 mL 7.4549 mL 18.6372 mL
5 mM 0.1491 mL 0.7455 mL 1.4910 mL 3.7274 mL
10 mM 0.0745 mL 0.3727 mL 0.7455 mL 1.8637 mL
15 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2425 mL
20 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.9319 mL
25 mM 0.0298 mL 0.1491 mL 0.2982 mL 0.7455 mL
30 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.6212 mL
40 mM 0.0186 mL 0.0932 mL 0.1864 mL 0.4659 mL
50 mM 0.0149 mL 0.0745 mL 0.1491 mL 0.3727 mL
60 mM 0.0124 mL 0.0621 mL 0.1242 mL 0.3106 mL
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mLR12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mLR12mLR 12mLR-12OthersTAADBAPNInhibitorinhibitorinhibit

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