2. Anti-infection
  3. Parasite
  4. MMV019313

MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC50 of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite).

For research use only. We do not sell to patients.

MMV019313 Chemical Structure

MMV019313 Chemical Structure

CAS No. : 902630-14-2

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5 mg USD 388 In-stock
10 mg USD 620 In-stock
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MMV019313 Related Antibodies

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Description

MMV019313 is a potent, non-bisphosphonate inhibitor of farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) with an IC50 of 0.82 µM. MMV019313 has activity against P. falciparum (Parasite)[1].

In Vitro

MMV019313 potently inhibits P. falciparum parasite replication in cultured human erythrocytes with an EC50 value of 90 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MMV019313 Related Antibodies
Molecular Weight

397.53

Formula

C22H27N3O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C(S1)=CC2=C1C3=C(N(C)C2=O)C=CC=C3)NCCCN4CCCCCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (10.06 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5155 mL 12.5777 mL 25.1553 mL
5 mM 0.5031 mL 2.5155 mL 5.0311 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.54%

SDS (251 KB)

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5155 mL 12.5777 mL 25.1553 mL 62.8883 mL
5 mM 0.5031 mL 2.5155 mL 5.0311 mL 12.5777 mL
10 mM 0.2516 mL 1.2578 mL 2.5155 mL 6.2888 mL
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MMV019313 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMV019313902630-14-2MMV 019313MMV-019313ParasiteThiazoleSARPlasmodium falciparumMalariaFarnesyl/Geranylgeranyl diphosphate synthaseInhibitorinhibitorinhibit

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