MNK/PIM-IN-1

Cat. No.: HY-132867: FAQs
Data Sheet Handling Instructions

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MNK/PIM-IN-1 represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.

For research use only. We do not sell to patients.

MNK/PIM-IN-1 Chemical Structure

CAS No. : 2430792-91-7

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•Related Small Molecules:

•Related Proteins:

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PIM1 PIM2 PIM3

Biological Activity
Purity & Documentation
References
Customer Review

Description

MNK/PIM-IN-1 represents an innovative dual MNK/PIM inhibitor with a good pharmacokinetic profile.

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	GI₅₀	1.5 μM Compound: 21o	Antiproliferative activity against human HL-60 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis Antiproliferative activity against human HL-60 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis	[PMID: 34515481]
K562	GI₅₀	2.19 μM Compound: 21o	Antiproliferative activity against human K562 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis Antiproliferative activity against human K562 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis	[PMID: 34515481]
MOLM-13	GI₅₀	1.23 μM Compound: 21o	Antiproliferative activity against human MOLM13 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis Antiproliferative activity against human MOLM13 cells assessed as reduction of cell viability incubated for 72 hrs by trypan blue staining based cell counting analysis	[PMID: 34515481]

Molecular Weight

486.54

Formula

C₂₇H₂₇FN₆O₂

CAS No.

2430792-91-7

SMILES

O=C(C1=CC=C(C2=NC3=C(NC4=CC=C(F)C=C4OC(C)C)N=CN=C3C=C2)C=C1)N5CCNCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Han Y, et al. Optimization of 4,6-Disubstituted Pyrido[3,2-d]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth. J Med Chem. 2021 Sep 23;64(18):13719-13735. [Content Brief]

MNK/PIM-IN-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNK/PIM-IN-12430792-91-7PimPim kinasesInhibitorinhibitorinhibit

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