2. Cell Cycle/DNA Damage Immunology/Inflammation
  3. Checkpoint Kinase (Chk) IFNAR
  4. Monalizumab

Monalizumab  (Synonyms: IPH2201)

Cat. No.: HY-P99032 Purity: 95.00%
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Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC).

For research use only. We do not sell to patients.

CAS No. : 1228763-95-8

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Based on 2 publication(s) in Google Scholar

Monalizumab Related Antibodies

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Description

Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC)[1][2].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Monalizumab blocks NKG2A and enhances CLL NK-cell mediated cytotoxicity against HLA-E-expressing K562 cells[3].
Monalizumab enhances the Enzalutamide (HY-70002) (10 μM)-induced NK cell activation and killing of prostate cancer cells (LNCaP and 22Rv1)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Monalizumab Related Antibodies
In Vivo

Monalizumab (50  μg, intratumoral injections, together with 8 millions of activated NK cells) effectively inhibits tumor growth in xenografted HLA-E+ tumors in immunodeficient mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: immunodeficient mice xenografted with Cal-27 HLA-E high tumor cell[4]
Dosage: 50 μg, together with 8 millions of activated NK cells
Administration: intratumoral injections
Result: Shows a synergestic antitumor effect.
Enhanced NK-cell killing, and induces lysis of tumor cells.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Monalizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Purity & Documentation
References
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Monalizumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monalizumab1228763-95-8IPH2201IPH 2201IPH-2201Checkpoint Kinase (Chk)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorCancer immunotherapyCD8 T cellsNK cellsNKG2AInhibitory immune receptorHLA-E/Qa-1head and neck squamous cell carcinomacancer immunotherapyimmune checkpoint inhibitorsrecurrent or metastaticInhibitorinhibitorinhibit

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