2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Mongersen sodium

Mongersen sodium  (Synonyms: GED-0301 sodium)

Cat. No.: HY-145721A Purity: 95.25%
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Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice.

For research use only. We do not sell to patients.

DNA, d(P-thio)(G-T-m5C-G-C-C-C-C-T-T-C-T-C-C-C-m5C-G-C-A-G-C), sodium salt

Mongersen sodium Chemical Structure

CAS No. : 1443994-98-6

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Based on 1 publication(s) in Google Scholar

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Description

Mongersen sodium is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen sodium restores TGF-β1 activity leading to inhibition of inflammatory signals. Mongersen sodium can attenuate Crohn's disease-like experimental colitis in mice[1][2].

Molecular Weight

7044.00

Formula

C200H241N69O107P20S20Na20
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Mongersen (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Mongersen sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mongersen1443994-98-6GED-0301GED0301GED 0301TGF-beta/SmadTransforming growth factor betaoralSMAD7 antisense oligonucleotideTGF-β1Crohn's diseaseInhibitorinhibitorinhibit

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